and other drugs
9/11/03 From: lucsan
Studies Link Fluoride to Low IQ Scores index
intelligence declines as their natural drinking water fluoride levels increase,
concluded a Chinese study in the May 2003 journal, Fluoride. (Abstract
comparable to those of U.S. water supplies treated to prevent tooth decay
were associated with inferior IQ scores.
The test subjects
were 512 children, aged 8-13 years from Wamiao, a high-fluoride village,
and Xinhuai, a low-fluoride village. The high-fluoride village was divided
into five subgroups by water fluoride levels, from 0.62 mg fluoride per
Liter to 4.38 mg F/L. As water fluoride levels increased within the high
fluoride village, IQ decreased.
"When the data
from the 512 children in the two villages were considered as a whole, a
significant inverse correlation was found between IQ and the level of fluoride
in urine," the researchers report. "These results are consistent with the
findings recorded by Li at al., Zhao et al., and Lu et al. of an inverse
correlation between intelligence and dietary fluoride from either contaminated
food or drinking water," they report.
experiences coal burning pollution nor do residents drink brick tea, two
common fluoride sources in China. Children with brain disease or head injury
history were excluded. Only water fluoride levels differed between the
two rural, low-income villages situated in the same province (Jiangsu)
and county. Neither blood lead levels nor urinary iodine differed between
the test groups. The researchers also controlled for family income and
the blood-brain barrier producing biochemical and functional impairment
of the nervous system during the developmental periods of infancy and childhood,
the authors report.
growing evidence of serious neurotoxicity for both fluoride and lead, U.S.
safety standards for fluoride in water have been moving in the opposite
direction to those for lead in blood. From a scientific standpoint, this
is very difficult to understand or to justify," says organic chemist Albert
Burgstahler, Ph.D., the editor of Fluoride.
Albert Burgstahler, firstname.lastname@example.org, www.fluoride-journal.com
Agency Bans Paxil Use in Children index
The New Haven
Register reports that the Connecticut Department of Children and Families
(DCF) is the first state agency to ban the use of Paxil in children to
protect them from harm.
of evidence demonstrating Paxil's suicide risk prompted the UK government
to issue a strong warning against pediatric use of the anti-depressant,
sold there under the name Seroxat, in June. It also led the manufacturer,
GlaxoSmithKline, to send healthcare professionals in the UK a letter warning
them about both the suicide risk for children and withdrawal symptoms.
has issued no such warning letter to US healthcare workers.
In July, DCF
became the first public child protection agency to ban Paxil after the
U.S. Food and Drug Administration recommended the drug not be given to
anyone under 18. The FDA said there could be severe negative effects for
children, including an increased risk of suicide.
DCF program supervisor for the Bureau of Child Welfare Services, said last
month the department is stopping use of Paxil for six months pending further
DCF will recommend
children on Paxil switch to safer alternative treatment, if one is available.
officials wouldn't reveal how many of the nearly 8,000 children in their
care are prescribed Paxil or other selective serotonin reuptake inhibitors
(SSRIs), saying that would violate patient privacy rights.
The FDA has
never approved use of Paxil in children or teens, but some doctors prescribe
the adult drug for children.
The FDA asked
all makers of adult antidepressants to submit research showing how their
drugs affect children. Three studies of Paxil found it didn't seem to help
pediatric depression - but FDA scientists spotted some safety concerns
and ordered manufacturer Glaxo-SmithKline to re-analyze the data.
found the risk of suicidal thoughts and suicide attempts was three times
greater among Paxil users, mostly teens, than among children given placebo
pills, the FDA said.
Warning Re: Use on Children index
the heels of the Paxil warnings, yet another drug company is cautioning
that their antidepressant drug should not be prescribed to children because
it may cause suicidal thoughts or self-harm. Wyeth Pharmaceuticals Inc.,
based in New Jersey, has sent a letter to healthcare professionals across
the country warning of possible problems with giving Effexor to children.
In a two-page
letter dated Aug. 22, Dr. Victoria Kusiak, Wyeth's vice
for global medical affairs, warned that in recent clinical trials Effexor
was not effective in treating depression or anxiety and that there were
increased "reports of hostility and especially in Major Depressive Disorder,
suicide-related adverse events such as suicidal ideation and self-harm."
In a prospective
trial published in the July issue of the Archives of General Psychiatry,
newborns of mothers receiving fluoxetine (Prozac) or citalopram (Celexa)
exhibited symptoms of central serotonin overstimulation for about four
days. The investigators warned of potential neurologic adverse effects
from selective serotonin reuptake inhibitors (SSRIs) used during late pregnancy.
(Arch Gen Psychiatry. 2003;60:720-726)
gained wide acceptance in the treatment of mental disorders in pregnant
women, but there seems to be an increased risk for neonatal adaptation
problems after exposure to SSRIs in late pregnancy," the article quoted
Kari Laine, MD, PhD, from the University of Turku in Finland, and colleagues.
They cited previous studies suggesting that exposure to SSRIs during the
third trimester may cause irritability, constant crying, eating and sleeping
difficulties, and even seizures in newborns.